Wow, not often you see a watch of that style in such good condition with the original box. I can't tell you any more about it I'm afraid but there are others here who can. How did you "acquire" it?
Reference 2443 as shown in the 1945 catalogue here;
These were illustrations so the fact the hands on your one are different than the sketch is not surprising. If you look at other models of the time from Heuer they used quite a few different hand sets across similar models.
A watch to cherish, especially as it’s from your uncle. I hope you’ll wear it.